Curriculum Vitae
Richard W. Bianco

Education
Professional Experience
Honors and Awards
Patent Applications
Internal Committees
External Committees
Professional Memberships
Federal Research Funding
Invited Speaker
Abstracts
 

EDUCATION:

Mayo High School, Rochester, MN 1972
University of Minnesota - B.A. 1976
University of Minnesota Graduate School 1985-1988
Program in CV Physiology

PROFESSIONAL  EXPERIENCE:

1972-1976 Surgical Technician, Mayo Clinic, Rochester, MN
(full-time and part-time)

1976-1978 Research Scientist, Cardiovascular Surgery Research,
Mayo Clinic, Rochester, MN

1978-1981 Junior Scientist, Department of Surgery, Division of
Cardiothoracic Surgery, University of Minnesota, Minneapolis, MN

1981-1989 Associate Scientist, Department of Surgery, Division of
Cardiothoracic Surgery, University of Minnesota, Minneapolis, MN

1985-1987 Director, Cardiovascular Surgical Research Laboratories,
University of Minnesota, Minneapolis, MN

1985-1994 Member, Board of Directors, Biomedical Research and
Development of Minneapolis, Inc.

1989-1995 Director, Cardiovascular Surgical Research Laboratories,
University of Minnesota, Minneapolis, MN

1989-1995 Senior Scientist, Department of Surgery, Division of
Cardiothoracic Surgery, University of Minnesota, Minneapolis, MN

1995-Present Program Director, Experimental Surgical Laboratories,
University of Minnesota, Minneapolis, MN

1996-1998 Special Assistant to the Senior Vice President for Health Sciences, University of Minnesota, Minneapolis, MN

1995-Present Institutional Official for Animal Care and Use,
University of Minnesota, Minneapolis, MN

1998-Present Associate Vice President for Regulatory Affairs
Academic Health Center, University of Minnesota, Minneapolis, MN

2007-Present Associate Professor of Surgery, University of Minnesota,
Minneapolis, MN

2000-2007 Assistant Professor of Surgery, University of Minnesota,
Minneapolis, MN

HONORS AND AWARDS:

1998 University of Minnesota Academic Staff Award

PATENT APPLICATIONS:

"Non-Invasive Detection of Rejection in Heart Transplant Patients"

INTERNAL COMMITTEES:

Civil Service Grievance Committee, 1981-1992
Institutional Review Board, 1985-1997
University Animal Care and Use Committee, 1988-1996
Co-Chairman, University Animal Care and Use Committee, 1989-1990
Chairman, University Animal Care and Use Committee, 1990-1996
University Animal Care Advisory Committee, 1991-1996
Member, Biomedical Ethics Committee University Hospital, 1992-1994
Vice Chairman, Institutional Review Board, 1994-1997
Search Committee for Director of Research Animal Resources, 1995
Institutional Review Board Executive and Investigative Committee, 1995-1997
Department of Surgery Advisory Council   1995-Present
Medical School Task Force - Research Services Chairman, 1995-1996
Search Committee for Assistant Director of ORTTA, 1996-1997
Research Services Organization Task Force, 1996-1997
RSO Research Process Managers Search Committee, 1997
Director of Research Services Office Search Committee, 1997
Resources and Research Ethics and Regulatory Compliance Committee, 1997
Controlled Substances Policy Committee, 1997- 1998
Department of Surgery Research and Grants Management Committee, Chairman,  1997 - Present
Medical School Administrative Restructuring Committee Research Task Force, 1997
Campus Safety and Security Committee, 1997 - Present
Institutional Compliance Committee, 1997- Present
Conflict Review Executive Committee, 1999 - Present
Lillihei Heart Institute Board of Directors, 2000 - Present
Council of Research Associate Deans, 2002 - Present
Conflict Of Interest Policy Revisions Committee Chairman, 2004 - 2006
Compliance Cooperation Workgroup, 2004 - Present
Occupational Health Workgroup, 2004 - Present
Senate Research Committee, 2004 - Present
Emergency Response Team, 2005 - Present
Occupational Health & Safety Work Group, 2005 - 2006
Institutional Official for Biosafety, 2006 - Present

EXTERNAL COMMITTEES:

 Co-Chairman, Subcommittee on the Development of May, 1985
    International Standards Governing in vivo
    Animal Testing of Prosthetic Valves, London, England

AAMI Cardiac Valve Prostheses Committee, 1989 - Present
    (Association for the Advancement of Medical Instrumentation)

The American Heart Association, Minnesota Affiliate
    Basic Science Council, 1984 - Present
    Communications Subcommittee (Co-Chairman), 1984 - 1985
    Component Relations Committee, 1984 - 1992

International Standards Cardiac Valve Committee, 1992 - Present

National Association for Biomedical Research, 1997 - Present
    Board of Directors
    Executive Committee, 1998 - Present

Academy of Surgical Research
    Board of Directors, 1998 - Present

Americans for Medical Progress, 2001 - Present
    Board of Directors

Journal of Heart Valve Disease, 2002 - Present
    Scientific Advisory Board

AAALAC Council on Accreditation, 2004 - 2007
    Site Visitor

International Standards Organization Co Chairman, 2006 - Present
    Vascular Prosthesis Working group

PROFESSIONAL MEMBERSHIPS:

The American Heart Association, Minnesota Affiliate, 1983-Present
Society for Biomaterials, 1987-Present
Member, Academy of Surgical Research, 1989-Present
American Society for Artificial Internal Organs, 1992-Present
Consultant, American Association for Accreditation of Laboratory Animal Care, 1993-1996
Member, Society for Heart Valve Disease, 2000 - Present
Member, Heart Valve Society of America, 2005 - Present

FEDERAL RESEARCH FUNDING:

Active:

R01 HL59730 Mechanisms of Polyurethane Valve Calcification in the Sheep Model
Robert Levy – PI, Richard W. Bianco – Co-PI
08/01/01 – 07/31/05

Inactive:

2 RO1 HL38118-04A2 “Cardiovascular Calcification:  Pathophysiology & Treatment”
Robert J. Levy - PI, Richard W. Bianco - Co-PI
07/01/95-07/31/03

2 RO1 HL 54733   “Polyurethane Calcification, Mechanism and Inhibition”
Robert J. Levy - PI, Richard W. Bianco - Co-PI
07/07/97-07/31/03

2RO1 HL26640-11  “Adenosine Metabolism in Cardiac Surgery”
John E. Foker - PI; Richard W. Bianco - Co-PI
12/01/91 - 11/30/96

INVITED SPEAKER:

National Association for Biomedical Research.  Washington D.C. June. 1997.
“Animal Rights Campaigns Against Research- Are You Prepared?”

STS/AATS TechCon.  Fort Lauderdale January 2002.
“Snap-On Coronary Bypass Surgery: Preliminary Animal Studies”

North Carolina Association for Biomedical Research, Animal Research Issues Forum Durham NC; October 2002
“ Incident Response and Management”

10th BEMA Meeting. Improving Animal Model Development and Characterization Washington, D.C. October 2003.
“A Key Enabling Technology in Bringing New Combination Products to Market”

Secretary’s Advisory Committee on Human Research Protections Washington, D.C. April 2005
“Perspectives on the Role of the Institutional Official”

Association of American Medical Colleges Group on Institutional Advancement  New Orleans April 2005
“Advocating and Explaining Controversial Science”

Roundtable on Biomedical Engineering Materials and Applications (BEMA) 50 years of Small Diameter Vascular Grafts: Are We There Yet?  Woods Hole, MA July 2005
“Benchmarking/Regulatory Issues”

ABSTRACTS:

1. St. Cyr JA, Ward HB, Bianco RW, Kriett JM, Einzig S, Foker JE. Relationship between recovery of myocardial ATP levels and cardiac function following ischemia. Presented at the Minnesota Mining and Manufacturing Meeting, Minneapolis, MN, May 23, 1984.

2. St. Cyr JA, Bianco RW, Ascher NL, Foker JE. Consequences of ischemia on organ energy metabolism. Presented at the Minnesota Mining and Manufacturing Meeting, Minneapolis, MN, May 23, 1984.

3. St.Cyr JA, Bianco RW, Noren G, Staley N, Foker JE, Einzig S. Myocardial energy levels in cardiomyopathic turkeys. Presented at the Minnesota Mining and Manufacturing Meeting, Minneapolis, MN, May 23, 1984.

4. Tveter KJ, Bianco RW, Rasmussen TM, Clack RM, Foker JE. Sheep model for long term evaluation of mechanical prosthetic mitral valves. Proceedings of the 13th Annual Meeting of the Society for Biomaterials, p.261, June, 1987.

5. Tveter K, Bianco RW, Mahoney J, Einzig S, Foker J. Ribose requirement for ATP recovery following myocardial ischemia. FASEB J. 2:4:A1493, 1988.

6. Bianco RW, Clack RM, Lang GR, Tveter KJ, Foker JE, Runge WJ. Pathologic assessment of a tubular woven teflon sewing ring. Proceedings of the 15th Annual Meeting of the Society of Biomaterials, April, 1989.

7. Wolf MJ, Coscio MR, Bianco RW. Comparison of luminal surface observations of the healing response of an experimental small diameter woven dacron and expanded polytetraflouroethylene arterial prosthesis. Proceedings of the 49th Annual Meeting of the Electron Microscopy Society of America, pp. 26-27, August, 1991.

8. Frautschi JR, Phillips RE, Schoen FJ, Bianco RW. In vivo performance of a prosthetic polymer heart valve: patological evaluation, Surfaces in Biomaterials Symposium, 165, 1993.

9. Chinn JA, Frautschi JR, Phillips RE, Joshi R, Levy RJ, Schoen FJ, Bianco RW. In vitro and in vivo mineralization of polymers: further comparison with device performance, Gordon Conference, July 1993.

10. Bianco RW, Mrachek J, Blee T, Phillips R, Schoen F. Preclinical evaluation of a new pericardial bioprosthetic with dye-mediated photooxidized bovine pericardial tissue. ASAIO abstracts 24, 30, 1995.

11. Chinn JA, Frautschi JR, Phillips RE, Bianco RW. Comparison of in vitro and in vivo biostability of surface modified polymers as determined by radiolablel, Surfaces in Biomaterials Symposium, September 7-9, 1995, Minneapolis, MN.

12. Frautschi JR, Chinn JA, Phillips RE, Bianco RW, Schoen FJ. Surface modification of prototype polymer valves improves valve performance in the bovine model, Surfaces in Biomaterials Symposium, September 7-9, 1995, Minneapolis, MN.

13. Ouyang DW, Pederson TS, Salerno CT, Bolman III RM, Bianco RW. Long-term evaluation of stentless prosthetic aortic valves in juvenile sheep. Accepted for presentation at the Academy of Surgical Research, 13th Annual Meeting. September 4-6, 1997, San Antonio, TX. J Invest Surg 10:238, 1997.

14. Pederson TS, Ouyang DW, Salerno CT, Bolman III RM, Bianco RW. Long-term evaluation of mechanical aortic valves in sheep. Accepted for presentation at the Academy of Surgical Research, 13th Annual Meeting. September 4-6, 1997, San Antonio, TX. J Invest Surg 10:225, 1997.

15. Bianco RW. Preclinical in vivo assessment of a new bileaflet mechanical heart valve. XXIV Congress of the European Society for Artificial Organs. October 16-18, 1997, Budapest, Hungary. International Journal of Artificial Organs 20:504, 1997.

16. Brendzel AM, Bianco RW, Ewert D, McMeeking RM. Cardiac Annulus Tissue Compliance and Forces on Mechanical Valves. Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology Workshop on Prosthetic Heart Valves: Future Technologies. February 18-22, 1998, Hilton Head, SC.

17. Grehan JF, Hilbert SL, Salerno CT, Bianco RW. The development and evaluation of a swine model to assess the pre-clinical safety of intra-cardiac prosthetic devices. Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology Workshop on Prosthetic Heart Valves: Future Technologies. February 18-22, 1998, Hilton Head, SC.

18. Salerno CT, Bianco RW. In vivo pre-clinical heart valve evaluation. Surfaces in Biomaterials '98. September 2-5, 1998, Tucson, AZ.

19. Svendsen CA, Salerno CT, Friedenberg AS, Shumway SJ, Bianco RW. A canine model of saphenous vein coronary artery bypass. Academy of Surgical Research. October 1-3, 1998, Nashville, TN.

20. Svendsen CA, Kreykes NS, Kirchhof N, Butany J, Bianco RW. In vivo assessment of a photofixed bovine pericardial valve. Presented at the World Symposium on Heart Valve Disease, London, UK June 11-14, 1999. Journal of Heart Valve Disease, 1999.

21. Grehan JF, Hilbert SL, Lahti M, Salerno CT, Droel JS, Bianco RW. The development and evaluation of a swine model to assess the preclinical safety of mechanical heart valves. Presented at the World Symposium on Heart Valve Disease, London, UK June 11-14, 1999.

22. St.Cyr JA, Ward HB, Kriett JM, Alyono D, Einzig S, Bianco RW, Anderson RW, Foker JE.  Enhanced recovery of myocardial ATP levels following global ischemia. Proceedings of the 2nd International Congress on Myocardial and Cellular Bioenergetics and Compartmentation, Los Angeles, CA, 1984.

23. Bianco RW.  Pre-clinical Assessment of New or Modified Heart Valves.  Presented at the 31st Scand-LAS Annual Symposium, May 13-15, 2001, Aarhus Denmark

24. Frederick J Schoen, Matthew Ogle, Paul Ashworth, Richard W Bianco, Robert J Levy  Inhibition of Cusp and Aortic Wall Calcification in Ethanol and Aluminum Treated Heart Valves in Sheep: Efficacy and Safety.  Proceedings of the Society for Heart Valve Disease First Biannual Meeting, June 15 –18, 2001 London, UK

25. John F. Grehan, Ivan Casagrande, Elaine Oliveira, Paulo C. Santos, Clodualdo J. Pessa, Luis R. Gerola, Enio Buffolo, Matthew T. Lahti, Richard W. Bianco. A Juvenile Sheep Model for the Long-Term Evaluation of Stentless Bioprostheses Implanted as Aortic Root Replacements.  Proceedings of the Society for Heart Valve Disease First Biannual Meeting, June 15 –18, 2001 London, UK

26. Robert J. Levy, Matthew Ogle, Paul Ashworth, Richard Bianco, Frederick J. Schoen  Inhibition of Cusp and Aortic Wall Calcification in Ethanol and Aluminum Treated Heart Valves in Sheep II: Mechanism and Synergism.  Proceedings of the Society for Heart Valve Disease First Biannual Meeting, June 15 –18, 2001 London, UK

27. Bianco RW. Snap-On Coronary Bypass Surgery: Preclinical Feasability Study. Presented at STS/AATS TechCon 2002, January 26-27, 2002 Fort Lauderdale, FL

28. Bianco RW. Pre-Clinical Evaluation of New Heart Valves; State of the Art. Second Hilton Head Workshop on Prosthetic Heart Valves March 6-10, 2002 Hilton Head SC

29. Bianco RW. Emergency and Disaster Planning: How to Implement and Oversee Crisis Management. Presented at Dealing With Differences: Decisions on Animal Care and Use Conference Sponsored by PRIMR/ARENA March 24-26, 2002 Boston, MA

30. Bianco RW. Managing Statewide Jurisdiction Over Animals in Agriculture Experiment Stations Presented at Dealing With Differences: Decisions on Animal Care and Use Conference Sponsored by PRIMR/ARENA March 24-26, 2002 Boston, MA

31. Bianco RW. The Role of the Responsible Institutional Official, Including General Organizational and Administrative Responsibilities, in Supporting the IACUC.  Presented at Dealing With Differences: Decisions on Animal Care and Use Conference Sponsored by PRIMR/ARENA March 24-26, 2002 Boston, MA

32. JF Grehan, MT Lahti, RW Bianco, Orthotopic Aortic Valve Replacement in Domestic Sheep. Proceedings of the Biointerface 2002 Symposium Surfaces in Biomaterials Foundation September 4-6, 2002, Scottsdale Arizona.

33. Kiyotaka Fukamachi, MD, PhD, Masahiro Inoue, MD, PhD, Zoran B. Popović, MD, Kazuyoshi Doi, MD, Soren Schenk, MD, Hassan Nemeh, MD, Yoshio Ootaki, MD, PhD, Michael W. Kopcak, Jr. MS, Raymond Dessoffy, AA, James D. Thomas, MD, Richard W. Bianco, James Berry, Patrick M. McCarthy, MD, Off-pump Mitral Valve Repair Using the Coapsys Device: A pilot Study in a Pacing Induced Model of Functional Mitral Regurgitation Running Head: Off-pump MV Repair Using the Coapsys. Presented at Society of Thoracic Surgeons Annual Meeting January 29 – February 3, 2003, San Diego CA

34. Robert Gallegos M.D, Xunhai Xu, Avinash Jayaswal, Christina Clarkson DVM, Eric Rahrmann, Zack Kastenberg, Xiaoen Wang, Imran Al-Amin, Rave Teja Seethamraju, Norbert Wilke M.D, Michael Jerosch-Herold, Catherine M. Verfaillie M.D, Richard W. Bianco, R. Morton Bolman III, M.D. Effect of Cardiac Stem Cell Therapy in Chronic Ischemic Canine Model.  Proceedings of Alfred Michaels Medical Student Symposium, March 17, 2003. University of Minnesota Minneapolis, MN

35. RP Gallegos, C Swingen, X Wang, XJ Xu, E Rahrmann, C Clarkson, RW Bianco, M Jerosch-Herold, RM Bolman III, Infarct Extent by MRI Correlates With Peak. Proceedings of the American Heart Asociation XVth Inter-American Society of Hypertension Scientific Meeting, April 27-30, 2003, San Antonio TX

36. Stanley J. Stachelek, Cunxian Song, Ivan Alferiev, DeFelice Suzanne, Xiumin Cui, Jeanne M. Connolly, Richard W. Bianco, Robert J. Levy Localized Gene Delivery from Polyurethane Heart Valve Cusps and Vascular Implants Using Antibody Tethered Adenovirus Proceedings of the American Society of Gene Therapy. June 4-8, 2003, Washington D.C.

37. RP Gallegos, JF Grehan, N Kirchoff, MT Lahti, RW Bianco, Pre-Clinical Evaluation of the Triflo Tri-Leaflet Valve; First Long Term In-Vivo Experience with a Tri-Leflet Design. Proceedings of Second Biennial Meeting of the Society for Heart Valve Disease - June 28, 2003 Paris France

38. RP Gallegos, A Rivard, C Swingen, M Jerosch-Herold, RW Bianco, Cardiac MRI in the Isolated Porcine Heart Reveals Possible Etiology of Sudden Right Ventricle Failure Following Cardiac Transplantation.  Proceedings of Cardiovascular Imaging 2003: 31st Annual Meeting & Scientific Sessions, September 13-16, 2003, Dallas TX

39. Michael F. Wolf, L.Yunker, P.V. Trescony, R.W. Bianco, J. Meinhart, J.M Anderson, Multifactorial Approach to Development of an OR-Friendly One-Step Vascular Graft Seeding Procedure.   Proceedings of International Conference on advances in biomaterials for Drug Delivery and Regenerative Medicine, June 11-16 2006, Capri Italy